We all have had an exciting year !
Here are some of our pending publications and patents as of November 11th, 2020
1. Preclinical studies for plant-based oral enzyme replacement therapy (Oral-ERT) in acid maltase deficient mice with transgenic tobacco seeds expressing human GAA (tobrhGAA). Frank Martiniuk, Adra Mack, Justin Martiniuk, Gregory O. Voronin, Shoreh Miller, David Reimer, Nancy Rossi, Sussan Saleh, Ruby Gupta, Mariel Nigro, Leslie Sheppard Bird, Feng Wu, Angelo Kambitsis, John Arvanitopoulos. Elena Arvanitopoulos and Kam-Meng Tchou-Wong
2. Rescue of mis-splicing for the IVS1 -13t->g leaky splice mutation in acid maltase deficiency or Pompe’s disease with valproic acid. Frank Martiniuk, Elena Arvanitopoulos, Angelo Kambitsis and Yanni Arvanitopoulos
3. Crotamine as a vehicle for nonviral gene delivery for acid maltase deficiency. Frank Martiniuk, Adra Mack, Justin Martiniuk, Elena Arvanitopoulos, Angelo Kambitsis and John Arvanitopoulos. https://connect.biorxiv.org/qr/2021.03.23.436632. 10.1101/2021.03.23.436632
4. Treatment of acid maltase deficiency or Pompe’s disease with ground germinated barley. Frank Martiniuk, Adra Mack, Justin Martiniuk, Elena Arvanitopoulos, Angelo Kambitsis and John Arvanitopoulos
5. Increased daily activity in wild-type mice fed germinated barley. Frank Martiniuk, Adra Mack, Justin Martiniuk, Elena Arvanitopoulos, Angelo Kambitsis and John Arvanitopoulos
6. Dattner AM, Martiniuk F, and Levis WR. In Vitro Clonal Priming Data Suggests Mechanism for Lower Initial Vaccine Dose Yielding Increased Immunity in Astra-Zeneca Vaccine Trial. J Drugs Dermatol. 20:483-484, 2021.
Provisional Patent filed 08/19/2020 Application number US 63/067,483 METHODS AND COMPOSITIONS FOR TREATMENT OF LYSOSOMAL STORAGE DISORDERS Inventors- Frank Martiniuk, Angelo Kambitsis and John Arvanitopoulos and Elena Arvanitopoulos, assignee JME Group Inc.
Oral Formulations for Enzyme Replacement Therapy of Human Lysosomal and Metabolic Diseases, Inventors: Frank Martiniuk and Kam-Meng Tchou-Wong; Assignee: NYU School of Medicine; serial #61/846,135, PCT patent submitted, 7-15-14.
Heat shock proteins from Mycobacterium leprae and uses thereof. Inventors: Frank Martiniuk and William Levis; Assignee: NYU School of Medicine. 20070160621.
20010027250 An activator protein of human acid maltase and uses thereof. Inventor: Frank Martiniuk; inventor.
Provisional Patent filed 08/19/2020 Application number : US 63 / 067,483
Methods and compositions for treatments of Lysosomal storage disorders inventors - Frank Martiniuk and Elena Arvanitpoulos , assignee JME Group Inc
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